Endocrine Abstracts

Introduction: ACTH-secreting macroadenomas account for about 4–10% of Cushing’s disease and are often resistant to surgical treatment and radiotherapy. The aim of the study was to present diagnostic and therapeutic difficulties in a case of cyclic recurrent ACTH-dependent Cushing’s syndrome due to atypical pituitary adenoma.Case report: 50-year-old man with visceral obesity was referred to hospital because of poor control of diabetes and h...

Introduction: Horner’s syndrome represents a clinical symptom that may result from a variety of lesions both in the central and peripheral nervous system. It is a combination of ipsilateral ptosis, pupillary miosis and anisocoria, enophthalmos and facial anhydrosis induced by disruption of the sympathetic innervation of the eye anywhere along its three-neuron trail. Tumors are the most frequent causes of Horner’s syndrome.Aim: Aim of the study ...

Acromegaly is caused by growth hormone-secreting adenoma in more then 95% cases. Ectopic secretion of GH-RH is a rare cause of acromegaly accounting for less than 1% of all cases. The most frequent source of ectopic GHRH is bronchial carcinoid. Clinical and biochemical findings are similar in both conditions. A distinction of pituitary vs extrapituitary acromegaly is important in planning effective management and both reasons should be considered in the diagnostic process....

Spindle Cell Oncocytoma (SCO) is a neoplasm of the adenohypophysis, often pre-operatively misdiagnosed as pituitary macroadenoma due to its rarity. First described in 2002, 28 cases have been described. It is a benign tumour manifesting in adults with no sex predilection, classified as WHO Grade I. A 71-year-old woman presented with bitemporal hemianopia, secondary hypoadrenalism, hypothyroidism and hypogonadotrophic hypogonadism. Imaging in October 2017 confirmed a 18.0×...

Background: Hyperhidrosis is a debilitating disease that has a significant impact on quality of life. There is limited research and gudelines on the investigations and management of hyperhidrosis.Aims: To assess if investigations and treatment of hyperhidrosis meets NICE CKS July 2013 guidelines.Method: The term ‘hyperhidrosis’ was used as a keyword search on an electronic patient record. Letters were restricted to those ...

Background: Self-administration of anabolic steroids among bodybuilders is an underestimated problem, often not admitted by patients.Case presentaation: A 19 year old male (planning to study medicine!) presented with gynaecomastia, general malaise and erectile problems. Investigations revealed acute hepatitis: ALT 2125 U/L [Ref. range (RR)<45] and hypogonadotropic hypogonadism: LH – 1.6 IU/L [RR: 1.5-9.3], testosterone 0.214 ng/mL [RR: 2.49-8.36...

Background: The patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk due to the lifelong glucocorticoid therapy and the disease per se.Objective: To evaluate vascular and cardiac function in adults with CAH during optimal corticosteroid and fludrocortisone replacement therapy.Patients and methods: Cross-sectional study of 19 adults with CAH (age 23.7 years ±3.8; males 63%) compared to...

Purpose: We sought to determine if in the group of patients who underwent gynecologic abdominal interventions diabetes was an independent risk factor of perioperative complications.Material and methods: The study group included 62 women from both the diabetic and the control group who underwent elective gynecologic laparotomies such as hysterectomy or adnexectomy. The patients from diabetic group were pair-matched with patients without diabetes based on ...

Objective: Acromegaly has an important impact on health-related quality of life. The aim of study was to ascertain the quality of life of patients with uncontrolled vs controlled acromegaly and compared to those with non-functioning adenomas and healthy control group.Methods: 124 participants underwent a cross-sectional assessment including the quality of life (AcroQoL, WHOQoL BREF), psychiatric morbidity (GHQ-28) and acceptance of illness (AIS). The sam...

Introduction: Increased production of vasopressin plays a key role in the development of fluid retention and hyponatremia in patients with decompensated heart failure. Antidiuretic hormone deficiency in the course of diabetes insipidus leads to the loss of water, dehydration and hypernatremia. The aim of the study was to present difficulties in successful treatment of hyponatremia in a patient with cardiomyopathy and heart failure, receiving desmopressin because of postoperati...